Good things come in small packages. That's true for Penta Guide, a 6 x 6 inch cube that is used around the world—wherever radiation therapy is used—to ensure that cancer therapy is delivered precisely and accurately. Made in London Ontario, Penta Guide was developed by researchers at the Princess Margaret Cancer Centre, which is part of Toronto's University Health Network. Celebrate the ways in which creativity, innovation and a collaborative spirit can translate to big benefits for patients, the economy and job creation. #creativityandinnovationday #innovation #technology #tech #design #business #engineering #science #creativity #medical #cancer #radiationtherapy

A study led by Dr. Kristin Musselman at the KITE Research Institute studied the benefits of a balance training program for individuals recovering from ‘incomplete’ spinal cord injury (when the spinal cord is not entirely cut and recovery can occur). Link to related news story: http://www.uhnresearch.ca/news/balancing-act Link to scientific article: https://doi.org/10.1186/s12984-021-00861-z To learn more about the exciting work taking place at Canada's largest research hospital, check out the 2022 UHN Research Report (digital version): https://online.flipbuilder.com/ubbi/favn/

Research led by Krembil Senior Scientist Dr. Nigil Haroon is focused on a protein called macrophage migration inhibitory factor (MIF). His team's findings lay the foundation for new treatment strategies for axial spondyloarthritis, a debilitating form of arthritis. Link to related story: https://www.uhnresearch.ca/news/homing-target Link to scientific article: https://doi.org/10.1126/scitranslmed.abg1210 To learn more about the exciting work taking place at Canada's largest research hospital, check out the 2022 UHN Research Report (digital version): https://online.flipbuilder.com/ubbi/favn/

By exploring new anticancer drug combinations to treat acute myeloid leukemia, Dr. Steven Chan's research program at UHN's Princess Margaret Cancer Centre is paving the way for clinical trials. Link to related news story: http://www.uhnresearch.ca/news/path-least-resistance Link to scientific article #1: https://doi.org/10.1016/j.stem.2021.06.004 Link to scientific article #2: https://doi.org/10.1038/s41375-021-01468-y To learn more about the exciting work taking place at Canada's largest research hospital, check out the 2022 UHN Research Report (digital version): https://online.flipbuilder.com/ubbi/favn/

A study from the laboratory of Dr. Cristina Nostro reveals a new approach for purifying therapeutic cells that could be used to treat type 1 diabetes. “For experimental therapies to be moved to the clinic, safety always comes first, and our findings provide an important strategy to reduce unwanted and potentially serious complications,” explains Dr. Nostro. Link to related news story: http://www.uhnresearch.ca/news/one-less-roadblock Link to scientific article: https://doi.org/10.1016/j.stemcr.2022.03.004 To learn more about the exciting work taking place at Canada's largest research hospital, check out the 2022 UHN Research Report (digital version): https://online.flipbuilder.com/ubbi/favn/

Research led by Dr. Stella Ng at The Institute for Education Research (TIER) revealed that teaching critical reflection can shift the focus of health care professionals towards more collaborative, compassionate and equitable ways of thinking. Link to related news story: https://www.uhnresearch.ca/news/learning-how-see-critically Link to scientific article: https://link.springer.com/article/10.1007/s10459-021-10087-2 To learn more about the exciting work taking place at Canada's largest research hospital, check out the 2022 UHN Research Report (digital version): https://online.flipbuilder.com/ubbi/favn/

The two studies featured here were led by first authors Drs. Aadil Ali and Aizhou Wang in the lab of Dr. Marcelo Cypel at UHN's Toronto General Research Hospital Institute. The first study revealed that storing lungs at 10oC, rather than the 4oC ‘gold standard’ storage temperature, doubles the time that they can be safely preserved. The second study explored a way to change the blood type of donor organs—an important step towards creating universal organs that would be compatible with all patients. Link to related story #1: https://www.uhnresearch.ca/news/warm-comfort Link to scientific article #1: https://www.science.org/doi/10.1126/scitranslmed.abm7190 Link to related story #2: http://www.uhnresearch.ca/news/future-organ-transplantation Link to scientific article #2: https://www.science.org/doi/10.1126/scitranslmed.abf7601 To learn more about the exciting work taking place at Canada's largest research hospital, check out the 2022 UHN Research Report (digital version): https://online.flipbuilder.com/ubbi/favn/

Dr. Gelareh Zadeh is one of this year’s recipients of the 2023 Canada Gairdner Momentum Awards. These awards recognize mid-career researchers who have made important discoveries that have the potential to improve human health. Dr. Zadeh will be recognized at the Gairdner Science Week in October. Dr. Zadeh is the the Head of Neurosurgery at Toronto Western Hospital, the Chair of Neurosurgery at the University of Toronto, Co-Director of the Krembil Brain Institute. She also leads a highly accomplished, peer-review funded, 30-member research team at the Princess Margaret Cancer Centre, where she is a Senior Scientist. Dr. Zadeh’s accomplishments have also been recognized through being named the Dan Family Chair in the Division of Neurosurgery at UofT—one of the world’s largest neurosurgical programs—making her the first woman in Canada to be named neurosurgery chair.